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Several of the region's universities (notably the University of Rochester and Rochester Institute of Technology) have renowned research programs.
By 1838, Rochester was the largest flour-producing city in the United States.
In 1950, the Census Bureau reported Rochester's population as 97.6% white and 2.3% black.
With industrial restructuring in the later 20th century, and the decline of industry and jobs in the area, by 2010, the city's population had declined to 210,565, although the metropolitan area was considerably larger.
Having doubled its population in only 10 years, Rochester became America's first "boomtown".
Rochester experienced one of the nation's biggest revivalist movements, led by Charles Finney.
In 1817, the Brown brothers and other landowners joined their lands with the Hundred Acre Tract to form the village of Rochesterville.